منابع مشابه
Pharmacogenetics Variations in Anesthesia
Pharmacogenetics is an emerging discipline that attempted to understand the hereditary basis for differences in responsiveness or inter-individual variation to therapeutic agents. It is the study of variability in drug response as a result of heredity factors. The importance for pharmacogenetics for the clinician is to enable optimum therapeutic efficacy, to avoid toxicity of those drugs whose ...
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Approximately 50 years ago, pharmacogenetics emerged as a new field of medicine that may explain human drug action. Anesthesia, in particular, played a key role in these early investigations. An understanding of how an individual’s genetic footprint influences drug metabolism and effectiveness may allow tailored prescriptions, improving outcomes and safety; and such concepts, which form the bac...
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To the Editor:—We congratulate Palmer et al. for their excellent review on pharmacogenetics of anesthetic and analgesic agents published in the March 2005 issue of ANESTHESIOLOGY. They give a worthreading introduction into basic molecular concepts and include the latest literature on pharmacogenetic aspects of anesthesia and analgesia. Because of this very comprehensive and detailed review, we ...
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When one discusses pharmacogenetics in cardiology practice, it is almost obligatory to discuss clopidogrel. Clopidogrel is an antiplatelet used for acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) with stenting, and as secondary stroke prevention in patients with aspirin allergy, among other indications. Clopidogrel is a prodrug that must be metabolized through the cytoch...
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Drug dependency is a highly prevalent mental health disorder that imposes a significant burden on those directly affected, health care systems, and society in general. There is substantial heritability in the susceptibility to drug addiction, which indicates that there are genetic risk factors. Variation in the human genome is abundant and can directly affect drug dependency phenotypes, for exa...
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ژورنال
عنوان ژورنال: Journal of Anesthesia & Clinical Research
سال: 2012
ISSN: 2155-6148
DOI: 10.4172/2155-6148.1000233